SIlent Hill 2 and SOMA both feature this, and in both cases I find it unsettling. It adds to the horror.
In SOMA,
In Silent Hill 2,
In SOMA,
it's because they're not actually people, just copies of them uploaded into hardware. They only can draw on previous experiences to respond to new ones, and as such, have no frame of reference for the hell around them.
In Silent Hill 2,
the protagonist James turns out to just be utterly fucking insane and unhinged.