* Saving a game, then quitting only to see the warning message "All unsaved progress will be deleted!!!!!". What the hell? It always makes my heart skip a beat and wonder if I'm about to lose all my stuff. I just saved, or how about you save my progress yourself? I like how Borderlands does it - when you quit it says "All your progress will be saved". Thank you Gearbox.
* Games that autosave with checkpoints, but still require you to save the game when you quit or lose all progress. Halo, I'm looking at you.
* Dying and then reloading. Feels archaic in 2011.
* Asking us to press START from the game menu, when you can usually hit any button to proceed.
* Games that confirm confirmations. Lookin at you GT5.
* Load screens that are nothing but a blank screen or little spinning load icon. There are way too many games guilty of this. If I have to wait, at least show me something interesting or let me interact with something. Bayonetta nailed this.
* Games that let you do batshit stupid shit your character would never, ever do. Like walk directly off of a cliff, or jump backwards onto spikes rather than over there to that handhold. At least have the character in game try to stop you at first, or say "Nuh uh", or even look directly at the screen and ask you "What the fuck are you doing?"