I will never stop talking about RE4. It is, in my opinion, the greatest game ever. I hate saying that for anything really, but it really just is for me.
I actually started with the GC version, my cousin had it, and I was playing it at his house. I didn't like it at the beginning (I didn't get to the chainsaw part), the controls were just so foreign to me at the time. I didn't understand the love for the game. So I didn't play it until the Wii version came out. And that was it, once I got to the chainsaw part at the beginning, I got it. I now understood why this game is so amazing. The Wii controls helped so much, it eased me into it.
There really isn't anything left to say that hasn't already been said, but I personally feel it is the only game that I can say is perfect. And that is very much subjective, but I have played it at least 15 times, and I can't recall a single second that I didn't like. It's just scary how good it is really.