It all depends where you're moving to and from.
When I switched from a small business to an academic environment, I made it very clear in my interview that I wanted to work on projects that were useful to the world, rather than to advertisers. I felt as though my previous job subordinated good, high quality editorial content to profitable, ad-friendly content.
Of course the irony is that now, 2 years later, every single advertising employee has left the company. Moved on to greener pastures. Because they didn't give a shit what the company was making, just how ads could be sold on it, and ads can be sold on anything. Meanwhile, the editorial department, who believe in their product, are largely still intact and working for the company. C'est la vie
If I had been applying to another small business, naturally I wouldn't have focused on that. I would have focused on the fact that there was little room for advancement at my previous job, or that I wanted to emphasize a different skillset, or whatever else.
It's also a dumb question to ask in an interview.