Yep, I think so too. Jill with a mix of 2/3 moveset and Wesker as previous reps.
I see Leon, Claire and, to a lesser extend, Ada as possible new characters.
Actually, Ada is much more likely than Claire. She brings more unique attributes to the table (grapple gun, high-tech spy equipment, acrobatics) and is much more popular than Claire.
With C. Viper being potentially dropped, Ada can replace the spy-with-cool-gadgets gimmick.
Grapple Gun can be incorporated into maneuvers and attacks like Spencer's.
Flash Bomb Glasses (from RE4) can be a teleport move.
Explosive Lipstick (from Darkside Chronicles) can be a long-ranged projectile attack.
High Heel Knife (from Damnation) can be a counter or something.
Timebomb Crossbow Bolt (from RE6) can function like Chris' proximity bomb.
Make-up Compact (from Darkside Chronicles) can be used as a healing or slow/stun the enemy for a while.