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Mask Efficacy |OT| Wuhan!! Got You All In Check

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ManaByte

Member


It's starting.

Come On Reaction GIF by GIPHY News
 

GamingKaiju

Member
Christ the EU are spitting their dummies out 😂

Anyway Boris has set an ambitious target for vaccination for 83% of the Country to have had the first shit by end of summer. I hope he pulls it off and Oxford gets the credit it deserves for getting an easily stored/transported effective vaccine 👍
 

dave_d

Member
I seem to remember some posters here being pretty sure that HCQ was no good. Despite being used worldwide by a lot of actual doctors. :pie_thinking:
All I know is early in the pandemic you'd hear all about how HCQ was experimental but no mention of the same for ventilators.(Both having mixed results) FWIW since it's a new virus all treatments are effectively experimental.
 

Chaplain

Member
Video: NEW COVID19 Variants (How Concerned Should We BE?) (1/27/21)

Genetic variants of COVID-19 are expected as viruses mutate all the time. Coronaviruses mutate slower than most RNA viruses, with an average rate of two nucleotide changes per month. A random mutation may make a virus more fit leading to an evolutionary advantage, as in what happens with natural selection, survival of the fittest.. from the viruses standpoint. …or the mutation could have no impact on its survival. Eventually, a viral variant with an evolutionary advantage will become the dominant form of the virus. Worldwide there are twelve key clades or variants of the SARS-CoV-2 virus. Sometimes the increased spread of a viral variant can only be attributed to chance. If a virus with a new mutation is carried by a super-spreader, moves to a new uninfected location, or is introduced to a new segment of the population, its rate of spread will increase. The U.K. variant has become the dominant variant in multiple regions of the world, which means it’s less likely a coincidence. Each time scientists identify a new variant. It raises the questions: does the mutation increase the viral transmission rate, does it cause more severe disease, and will the current vaccines or a previous infection still provide protection?

 

Loki

Count of Concision


It's starting.


What the hell? I assume this will affect the Oxford/Astra-Zeneca vaccine's availability in the US? Or was that being manufactured outside of Europe? That is literally the ONLY "traditional" vaccine for COVID, and the only one that I'd remotely entertain taking. Hopefully it will be available in the US.
 

Dr.Guru of Peru

played the long game
Well, this confirms what many of us assumed was happening back in 2020...


This is not a recommendation by the journal, its a review article published in the the journal that looks at numerous possible therapies (one of which is HCQ). It's also bizarre because the article was published now, because it seems to have been written in July of last year. Not a single one of its citations is after July 3rd, and it references COVID case numbers that we surpassed in April of last year.

Anyways, as has been discussed in this thread ad nauseum, we have numerous excellent quality randomized controlled times since then that have shown that HCQ is useless. There's a reason that Trump never took it when he became ill himself.
 
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Chaplain

Member
This is not a recommendation by the journal, its a review article published in the the journal that looks at numerous possible therapies (one of which is HCQ). It's also bizarre because the article was published now, because it seems to have been written in July of last year. Not a single one of its citations is after July 3rd, and it references COVID case numbers that we surpassed in April of last year.

Anyways, as has been discussed in this thread ad nauseum, we have numerous excellent quality randomized controlled times since then that have shown that HCQ is useless. There's a reason that Trump never took it when he became ill himself.
Thank you for taking the time to respond and excellent points all around.
 

Jezbollah

Member
What the hell? I assume this will affect the Oxford/Astra-Zeneca vaccine's availability in the US? Or was that being manufactured outside of Europe? That is literally the ONLY "traditional" vaccine for COVID, and the only one that I'd remotely entertain taking. Hopefully it will be available in the US.

It depends on where the US allocation is coming from - I know there are a few major plans in India making the vaccine.

But yes, the EU would have the power to block all vaccine exports, meaning they would be stopping the supply and inocculation to those in most need of it. The EU is literally playing with people's lives here.
 
Some numbers came out of the German report on the AZ vaccine, 1 out of 314 over 65 vaccinated got covid against 1 out of 391 in the placebo group. This technically means you're more likely to get ill with the vaccine. But one less and it would have had 100% protection, you're dealing with such low numbers that it only proves the vaccine does not harm the recipient.

Obviously the over-65 group was way too small to be useful but for the rest there is a 70% protection against getting symptoms and a 100% protection from getting hospitalized/dead for the rest so AZ can be used for under 65's until the UK comes with data on all the oldies who got the AZ vaccine. It's hard to imagine the vaccine just stops working after your 65th birthday and I expect it to be as effective as for the rest.
 
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DragoonKain

Neighbours from Hell
Whitney Cummings talked a lot about her experience with COVID on her latest pod. She said she had it really bad. No respiratory stuff, but she had major muscle aches, couldn’t keep food down, she had hallucinations and was delirious.
 

Jezbollah

Member
A really interesting series of tweets from BBC's economics editor Faisal Islam, please forgive the formatting, but thought it would be good to document here (thought it would be better to it this way rather than embed a dozen tweets)

Different type of vaccine being developed at Scottish factory of a French company - an “inactivated whole virus” - UK task force secured 60m dose preorder in July for €470m with options for 130m more 2022-25, invested in factory. EU finalised first order of 30m this month.

Basically the Government through @katebingham acted like a venture capital fund, funding many vaccine candidates, expensively, across different types of tech, with companies from different countries (at time of some scepticism that a working vaccine could be produced so quickly)

Though despite the fact French Valneva had been funded for its vaccines in general in 2018 by EU’s investment bank, UK funding guaranteed its production in UK (speculative VC style investment) - similarly UK signed deal with Pfizer for German developed/ funded Biontech vaccine

UK approach explicitly focussed on speed (and boosting poor UK vaccine supply chain), at expense of cost. cost of individual batches, and cost of investing in spread of vaccines, not all would eventually be needed/ used... EU focussed on lower price, & helping smaller EU nations

approach with Astra Zeneca went further
- UK Govt via Matt Hancock involved in matchmaking AZ with Oxford University, funded early clinical trials that eg enabled private jets to ferry samples etc - 100m doses and pricing at cost were part of that deal struck at April wave 1 peak

Important thing is AZ was not a vaccine specialist - alliance was encouraged by Govt, ie other possible ones being considered by Ox were effectively blocked by Hancock because of national interest. Not sure EU approach clocks intimate involvement/ risk taken by UK Govt here...

good news for everyone, is that UK should, in theory, have access to too much vaccine over course of this year, and could therefore be in a position to help. Already tens of millions of Oxford vaccine is being mass manufactured in India and shipped to other developing countries..

appropriate analogy here with EU would have been it at an early stage funding and developing Biontech in Germany (it did). But then at point Biontech did a deal with Pfizer, either have blocked that or insisted on first use in the EU, and paid handsomely, over odds for pleasure

Government playing EU-AZ spat very straight - even AZ supply chain stretches into EU. And we don’t know which is the best performing vaccine, and that matters as we expect this will become an annual event... UK, may yet be reliant on EU vaccines in future...

Things to discuss:
-Paying over odds for quicker vaccines, & for some vaccines which will never be used can still be vg value for money vs lockdown cost.
-Did UK turn necessity of coping with poor vaccine supply chain to advantage?
-Were EU listening overly to its big Pharma cos?


Great interview from @katebingham2 with Nick R - says that the NHS registry of 400k volunteers for super rapid clinical trials as well as help with manufacturing were crucial in getting round natural size disadvantage on vaccines. will be seen as post Brexit model - UK as “lab”

On AZ issue she points out UK was already building out Oxford vaccine manufacturing capacity from one year ago, two months before AZ deal signed (and at the time a deal was being negotiated with US company) AZ deal required those 100m doses for UK and at cost pricing

But it’s a race where you win much more than the total stake if any of your horses merely cross the line ... and you get your winnings more quickly the earlier the bet is placed...#

TLDR, UK Government and Oxford/Astrazenica vaccine was more than just a commercial deal, it was a proper investment from even before Oxford and AZ had an agreement. Investment into infrastructure and NHS volunteer resources was provided by the UK government, and UK first option for all UK produced Oxford/AZ vaccines was part of the deal struck last April. EU's deal for the Oxford/AZ vaccine was a commercial only deal with little investment (they invested elsewhere) and haggled for lower cost. EU now paying for that lack of investment with major supply issues.
 
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Jezbollah

Member


The EU flexing its powers and potentially witholding vaccines, while at the same time demanding those made in the UK.

Sinister, to say the least.
 

Chaplain

Member


Video: Teachers speak out: school closures are a disaster
For much of the past year, across Europe and the wider world, schools have been closed. Was this a morally justifiable policy? We spoke to teachers and one former teacher, now MP, to find out: what is the reality on the ground? What is the impact on children’s lives? At the end of it do we think it was the right decision? Katharine Birbalsingh, Headmistress of the Michaela Community School in northwest London. Miriam Cates MP, Conservative MP and former science teacher and Alex Gutentag, a public school teacher from Oakland in California. Each of them comes to a different conclusion but they agree on one thing: the impact on children of such an extended period of school closures is very grave.


Video: Coronavirus latest: What's behind the EU/AstraZeneca row? | SpectatorTV
Kate Andrews, James Forsyth and Katy Balls break down the latest coronavirus news with Andrew Neil. Kate Andrews, The Spectator's economics correspondent, examines the data driving the government's response to the crisis, while the political team assess the ongoing EU/AstraZeneca row.


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Jezbollah

Member
I would do the same as well.

The problem of that is they have invoked article 16 of the withdrawl agreement, essentally having put a hard border in between Northern Ireland and the Republic of Ireland. That was a nuke option only to be used in situations where all previous negotiatons have failed.

Yet they have used it in amazingly casual utility.

I honestly thought by mid afternoon today that the EU couldnt fuck up further. Now they have - and it puts the entire Northern Ireland agreement in danger because of their paranoia.
 
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THE:MILKMAN

Member


EU changed their mind. Utter shitshow.


Yep. I say a lot of this goes all the way back to the IVA being ready to sign a contract with AZ in June and then the EU came in and took over but didn't sign it for another two months. My guess is those IVA countries (Germany, France, Italy, Netherlands) and the rest of the EU countries affected all kicked off big time about the delays this caused and the EU shat the bed resulting in the crazy responses we've seen the last few days. Yes, AZ messed up on their end and are clearly out of their depth in some ways here but when even the Archbishop of Canterbury is calling the EU out on Twitter then you know you fucked up!

My opinion is they all should pause this spat, agree to get the issues sorted and the vaccines delivered and come back and fight it out later.
 

Jezbollah

Member
The funny thing is that there are reports of the EU demanding 50 million of the UK manufactured AZ vaccine to be sent to them. Even though the UK has first option on those made here

So the EU wants AZ to break their contract with the UK (who has been more than a partner in this venture) to satisfy their own contract.

It's a bold strategy Cotton....
 

segasonic

Member
A really interesting series of tweets from BBC's economics editor Faisal Islam, please forgive the formatting, but thought it would be good to document here (thought it would be better to it this way rather than embed a dozen tweets)



TLDR, UK Government and Oxford/Astrazenica vaccine was more than just a commercial deal, it was a proper investment from even before Oxford and AZ had an agreement. Investment into infrastructure and NHS volunteer resources was provided by the UK government, and UK first option for all UK produced Oxford/AZ vaccines was part of the deal struck last April. EU's deal for the Oxford/AZ vaccine was a commercial only deal with little investment (they invested elsewhere) and haggled for lower cost. EU now paying for that lack of investment with major supply issues.
Not true, AZ was handed 300M € by EU to ramp up production. It is also explicitly stated in the contract that all sites including UK sites are to produce the vaccine for EU. Lastly it is also specifically stated in the contract that the number of doses to be delivered will not be affected by obligations with other customers. The claims by the CEO that they have to deliver to UK first, because UK ordered first are bs. Essentially AZ tried to defraud EU by taking EU money then claiming some bullshit production problems at EU sites and exporting vaccine meant for EU to UK.

Eventually they will suffer for this. Just ask Microsoft or Google how it went for them...
 

DragoonKain

Neighbours from Hell
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.
 

Furlong

Banned
When the UK are ready to start sharing the AZ vaccine, it should only go to countries not included on the EU's exclusion list such as Australia.
 

Jezbollah

Member
Not true, AZ was handed 300M € by EU to ramp up production. It is also explicitly stated in the contract that all sites including UK sites are to produce the vaccine for EU. Lastly it is also specifically stated in the contract that the number of doses to be delivered will not be affected by obligations with other customers. The claims by the CEO that they have to deliver to UK first, because UK ordered first are bs. Essentially AZ tried to defraud EU by taking EU money then claiming some bullshit production problems at EU sites and exporting vaccine meant for EU to UK.

Eventually they will suffer for this. Just ask Microsoft or Google how it went for them...
The UK Government invested in facilities before arranging the deal between Oxford University, and subsequently provided facilities (essentially driving the early trials) and personel (via NHS Volunteer register) in the arrangement put together in April, and the 100m dose and option to have first dibs on all vaccine made in the UK was part of that. Feel free to review a series of tweets by BBC's Economics Editor Faisal Islam on that.

The EU deal with AZ is superceeded by the prior agreement by the UK for the stock made in the UK. What AZ do with their stock in the EU (either distribute within EU, or to the UK) is up to them. But the stock made in the UK is not up to them, because of that option. I suspect this is why the mention of "best endeavours" is so prolific in the EU contract.

The EU are not entitled to the stock from the UK, even if it states that they may demand it, because the UK Government decides what happens to that stock in the first instance. If you don't think this is the case, why do you think the UK has remained quiet and only stated that "we are comfortable with our supply chain"?

Do you hear any talk about going to the courts to determine who has right for the stock? No? Why is that? Because the EU would lose.

The smart move by the EU would have been to engage with the UK and AZ to transfer lessons learned by the UK AZ plans in September when they had their issues to the EU AZ factories that have their production issues. However, they went with full nuke option with Clause 16 and made themselves look more stupid.
 
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Chaplain

Member
Video: Heather Heying & Bret Weinstein: The Lab Theory | Real Time (HBO)

Evolutionary biologists Heather Heying and Bret Weinstein join Bill Maher to discuss the nature and possible origins of the SARS-CoV-2 coronavirus. (1/29/21)







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Chaplain

Member
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.

This sounds like a difficult place that you find yourself in. Sorry, bro.
 

Jezbollah

Member

Vaccine manufacturer Moderna has told Italy and France it will deliver fewer doses than expected in February, in another blow to struggling coronavirus vaccination plans in the EU. Domenico Arcuri, the Italian special commissioner in charge of Italy’s pandemic response, said Moderna had told Rome that delivery volumes would be 20 per cent less than planned from early February.


waiting for the EU to implode.....
 
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SpiceRacz

Member
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.

I wouldn't worry. I'd be more concerned about an allergic reaction than the vaccine interfering with your medications.
 

Jezbollah

Member
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.

If it helps perspective, the UK has now vaccinated 8 million people. They are the eldest demographic of age groups and most are likely to have preexisting conditions and are on various medications. My uncle has had both his jabs, and my mum is scheduled to get hers done on Wednesday.

We have yet to see any major publicity over any kind of serious conflict with either mediations or preexisting conditions apart from a couple of extremely hyperallergic people. I would suggest there's a lot of data taken from this already.

If you are concerned, give your doctor a call and have a chat about it, so you can make an informed decision for yourself.
 

DragoonKain

Neighbours from Hell
If it helps perspective, the UK has now vaccinated 8 million people. They are the eldest demographic of age groups and most are likely to have preexisting conditions and are on various medications. My uncle has had both his jabs, and my mum is scheduled to get hers done on Wednesday.

We have yet to see any major publicity over any kind of serious conflict with either mediations or preexisting conditions apart from a couple of extremely hyperallergic people. I would suggest there's a lot of data taken from this already.

If you are concerned, give your doctor a call and have a chat about it, so you can make an informed decision for yourself.
I have, he didn’t make a recommendation quite yet. He said he wanted to see if there’s so,e data by the time I get the call for the vaccine. If not, it’ll likely be my choice based on his recommendation. Right now I’m leaning toward it, but the meds I take are biological so it’s not like taking aspirin or whatever or typical allergy meds. I assume it would be ok and that many of the people who’ve gotten them are also on these drugs, as they’re often used to treat rheumatoid arthritis and since we’ve vaccinated many elderly people already, I assume a decent amount of them have taken these drugs to treat that, I think it would’ve been made known if there was any bad reaction.

but I’ll see. I don’t even know how it works really. I registered, I assume they’ll just call me.
 
D

Deleted member 17706

Unconfirmed Member
Isn't weird how it is evil to say "china virus" but its totally cool to say "britisch variant" or "brazilian variant"?

Shit, he's catching on. Quick, have the police shoot someone.
 

GamingKaiju

Member
If the B.1.1.7 variant becomes the dominant strain I wouldn’t mind it been called the English Flu.

Since the U.K. has had so many firsts during this pandemic the first in Europe for 3 million cases the largest death rate in Europe, the first to get a vaccine, so it makes sense that it’s own variant gets called after the U.K.
 

Jezbollah

Member
What's with all this sudden talk of Country X variant?

The variant is labelled after the location where it was traced back to in its earliest detection. Inevitibly, though, a country can only detect it if it's doing a large amount of genomic sequencing. The UK has basically done 50% of the entire genomic sequencing for COVID 19 globally - and the UK variant was discovered in Kent and couldnt be traced further back, hence the UK variant. Likewise for the South African and Brazillian variants - I believe thought that SA genomic sequencing caught that variant there. Not sure about the Brazillian one.
 
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