It has been a while since I have seen such unfriendly problems with a PC game.
Instant crash to the desktop after selecting "new game", with no error message regardless of any settings/compatibility mode/driver updates/etc.
Tried various graphics presets (high, medium, etc), with/without HD texture pack, running as 'Administrator', running in XP and 7 Compatibility mode.
Windows 8 with latest updates,
560 Ti, nVidia 306 and 310 drivers (not overclocking),
i5 2500k @ 4.2Ghz stable for 1.5 years prior to this.