IGN vid review made an interesting statement about the replayability. Apparently normal difficulty doesn't offer up a lot of challenge, but Jaffe's team cushioned this blow by adding extra incentives to completing the more difficult modes a second time through.
New levels, new enemies, expanded cutscenes and plotlines, etc.. VERY NICE.
Oh and since the DMC3 comparison posturing never ends, I might as well chime in with my largest dissapointment of DMC3...ultra lame enemies. I can take the occasionally awful camera positions, work around the save structure, and the difficulty...not a problem; but why is such a thrilling and graceful combat engine put to use against such blaise demon foes. Mostly just speaking of the game's second half; those purple cloud puffs, the chess pieces, the fallen angels...boy did DMC1 serve up a tighter roster of thugs to rip on. (Bosses notwithstanding)
Damn, I can't believe God of War, PSP and DW5 are all releasing so close.