UC3 had Drake beating up like 7 foot tall muscle grunts multiple times and the game started with clearing a whole pub with Sully in a fist fight. UC2 had Drake fighting an experienced evil warlord boss that had just got super powers. But he couldn't fight Nadine, the game didn't even let you get in a hit. She was beating both Sam and Nate's ass easily and she had no payoff in the story for it.
It's the only time in the series something like that happens and it was just lame, even if she had been a man.