You don't think the biggest 3DS games so far will make an appearance? I don't really understand your logic here.
Anyway, this E3 is impossible to screw up, although I know Nintendo will try. StreetsAhead's list has me really excited either way (yes, even after last year ;_.
It's more a question of what games they decide don't fit E3. Part of the reason people have problems with the conferences is because the companies see E3 as the best venue to reach out to the casual consumer who barely pays attention to videogames. So they save their "core" games for other occasions.