You can bet that 99% of the Fortune 500 companies and multinational organizations are going to make very very sure that Microsoft keeps Win32 support in, because all of those companies are in all likelihood running at least a few (more likely several) internal apps that make Big Rigs: Over The Road Racing look competently coded. This is software that is so specialized it effectively makes its company a monopoly in a specific industry, with guaranteed clientele no matter how shitty their software is and how many hoops they have to make their clients jump through in terms of disabling tons of security features in the OS and shit like that, because in these industries not having the software in question is simply not an option.
In all likelihood, big enough companies will have an SA subscription in order to run a specific locked-down version of Windows that they have to ensure doesn't change much. This means they are paying Microsoft a phenomenal amount of money (especially collectively) every year as part of a subscription, because, again, their business depends on it. Microsoft pulling Win32 support across the board all of a sudden, if their shareholders would even allow them to kill that golden goose (there is essentially 0% chance of this), would result in massive business implications to the point where I could flat-out see specific governments imposing that Microsoft keep in Win32 support or face huge fines and other sanctions. The governments might even force their hand and require older Win32 OSes be sold and supported, like what happened with Windows XP (you could still buy an XP machine from Dell until surprisingly recently, 2012 I think?) and Windows 7 (can still get a PC with Windows 7 from basically all the major vendors if you ask for it)