4790k /1060 @ 1080p / SSD / rtss framelimit @ 60
The auto-configuration put me at very high with all optional effects enabled. During the first big scene with a large room and many NPCs present I dropped from 60 down to low 40s, but dropping the preset from very high to high had no effect on FPS. After the scene plays out and you are given control of MC I went back to 60 and have been maintaining it through the first real gameplay area (haven't gotten to throne yet).
The TXAA implementation is very blurry; I hesitate to call it "bad" because I haven't done enough research on TXAA to know how much blurriness is expected, but it's very reminiscent of the blurriness in Mafia 3. Bumping back to FXAA sharpens up the image but seems to expose minor artifacting around some edges. I attempted to capture some images of the artifacting but it's not visible in still shots. It does seem like the problem with TXAA is also linked to some render distance issue, as though the aliasing is too strong within too short a radius of the player but looks okay further out at the same strength.
As someone who is very picky about input, mouse control seems fine to me with vsync both enabled and disabled. I haven't had control of input during a big frame drop area so that may change if vsync is enabled at the time. I have smoothing at 0 and friction off, and the mouse movement feels linear to me, but I'm a relatively low sensitivity FPSer so maybe I'm not seeing problems in acceleration etc.
Based on the fact that changing the preset didn't modify my framerate at all in the large area with many NPCs (and my GPU was pegged at 100% with vsync on in both presets) I suspect there might be problems with engine scaling in areas of complex/open geometry and/or when many entities are on-screen simultaneously. Subjectively, it's performing like more of a PC "port" than the original Dishonored did, in that it feels like some areas of the game may just not scale properly to 60fps on 970/1060 GPUs due to being designed against a 30fps target. I haven't played with the settings one by one though so it's entirely possible that there might be one or two that are causing issues rather than it being systemic.