Theory:
The Last of Us is revealed to be a prequel to Crash Bandicoot.
New game is announced. It is set between the two games, as mankind becomes virtually extinct and marsupials rise to power as the dominant species on Earth. You play as Jack Cortex, trying to survive in a dangerous world with no love for humankind. It'll continue with TLOU-style gameplay, in that Jack's son Neo (a quick-witted, yet horrifically deformed child) will play a pivotal role during gameplay.
Evidence that supports this is the sentient and hostile plants that still exist in Crash's time.