Kilroy said:
Speaking of Little Sisters, if Bioshock 2 wants to let the player make moral choices, make the choices interesting.
Harvesting Little Sisters was about as traumatic as changing my socks. The consequence of harvesting the slightly creepy looking girls? A green cloud and a sluglike creature. Yeah, I'm soo feeling guily now.
Two of the major themes in Bioshock were those of corruption and innocence. Ryan and his ideals were inherently corrupt, thus Rapture was doomed to spiral out of control. The advent of plasmid technology resulted in citizens willingly corrupting their bodies and sacrificing their humanity. As a counterpoint, I interpreted the little sisters as representing an image of true innocence: young naive girls corrupted by others for their own selfish purposes. Also, the player is assumed to be completely innocent upon his arrival
to Rapture, but ultimately corrupts himself against his free will and surrenders his innocence.
There was some complex symbolism there with those two themes that didn't really carry over to the gameplay. Also, no character in Rapture was truly morally good and evil- there was always a grey area of ambiguity when it came to each characters moral substance. It would be an improvement if the player actually felt some guilt or unease when it came to moral decisions, hopefully something that transcends the Mass Effect system of 'Upper Right for Good, Lower Right for Evil' moral responses.
Plasmids or abilities like them will appear in the sequel. I don't think we will play as Jack again, but I think there is more to Jack than what we saw in the first game. If there are detective puzzle-solving aspects to this game, that would allow for a multitude of creative gameplay possibilities. This game is from the people that made Thief, so they will certainly be able to handle those aspects well.