Sadly I'm not expecting much from them at E3.
My insane and crazy wishlist:
SUPER Mario - an open world game and mario can level up and get new powers (run faster, jump higher, fireballs, ice...think crackdown or infamous) and set in the mushroom kingdom or possibly a new world completely. And no bowser...some other bosses
Super Metroid U - side scrolling Metriod. A sequel to Super Metroid with some beautiful graphics and huge areas to explore
Animal Crossing U - similar to skylanders. Collect all the villagers in stores and have them in your town. More stuff to do. More stores and different islands
Zelda U - huge open world Zelda. Go anywhere and do anything. Have a level up system. Buy different armors and other accessories.
Starfox U - great space battles. Also go to different open world planets
3rd pillar - 5in single touch screen device. Much more powerful than 3DS. Most Wii U games can be easily ported ( I do realize that graphics will not be the same...I'm ok with that as long as gameplay is great). Have TV out. Can play on TV or take with you.
Virtual Console - Everything NES, SNES, N64, GBA game available day one. Add Gamecube, Dreamcast, etc over time. You can buy on Wii U or new 3rd pillar device and can download on either and play.
I do realize this is a crazy list. Would love it if at least one or two of these happened