Yeah, I know he said it's 'not about optimisitaion', but it is. There's no way this game needs 5GB RAM if something like Xenoblade/Super Mario Galaxy can run on 88MB.
I was worried that having so much RAM would result in devs just writing lazy, bloated, unoptimised code, rather than actually making good use of the extra power. I guess it makes sense for indie games, but I hope we don't see this kind of thing in AAA releases
EDIT: In fairness, we haven't seen anything of the game, so saying there's 'no way' is a bit short sighted I guess. But still, I highly doubt it.