*puts on his doctor cap*
I really don't see how chromosomal anomalies have anything at all to do with what you're trying to say. Not only are they anomalies that any good scientific study on traditional gender genetics would throw out but they also don't particularly apply to the transgender community at large. As far as I'm aware, most transgender people do not have chromosomal anomalies. Furthermore, it doesn't really seem like you have a firm grasp of how genetics work in terms of gene expression, the effects of mutations on alleles, and how that correlates to human biological development. Maybe you actually have a background in science so forgive me for that assumption if I'm wrong, but in all honesty, it's ironic that you're accusing someone of using pseudoscience when that seems to be exactly what you're doing here.
If we're talking about the significance of sex chromosomes within the transgender population, chromosomal anomalies that lead to abnormal development aren't particularly pertinent since, please correct me if I'm wrong here, the majority of the transgender population have perfectly normal sets of sex chromosomes. Chromosomal anomalies don't suddenly mean sex chromosomes are inconsequential. Again, it's a bit ironic since the mutations you listed have severe developmental consequences and one of the biggest mantras of the transgender people that I'm at least familiar with is the idea that their biological development has been normal but does not fit their cognitive identity, thus cementing the fact that there's nothing actually wrong with them aside from the contradiction in identity and biology.
It seems like you're trying to say "there is no need to ask about chromosomes when addressing a transgender person because they do not dictate gender identity" by affirming that chromosomes somehow don't matter. Well I would certainly agree with the former, and the latter is acceptable as well as long as it's accompanied with an addendum that states they don't matter insofar as the value of the person in question as well as their gender identity are concerned. That of course is completely true. But saying they don't matter at all seems to be an attempt to affirm that they don't mean anything whatsoever, that they don't even exist. Which of course is absurd and not what you're saying directly but it seems to be the point behind your arguments. It's undeniable that chromosomes DO matter, that's the whole reason why transgender people decide to transition in the first place! The fact that the human body is pliable and can be remolded to a certain degree with the use of hormones does not somehow negate the reality that chromosomes exist even if their efficacy is diminished. And even then, there are multitudes of other issues that arise with hormone therapy, dangers and concerns that I'm sure you're well aware off, that aren't common concerns for the general population. That's just another way those pesky chromosomes are making a difference.
Just to clarify, I only bring this up as a matter of scientific clarification. I don't think it's appropriate to bring up a transgender person's chromosomes as that is obviously a bit of a sensitive subject and an area that is easy to raise offense. So if you happen to be transgender or there are other who are sensitive to the matter, understand I bring it up not to rub it in someone's face but rather simply because this is actually a field that I'm very familiar with and am approaching it merely in an academic sense, especially since you brazenly accused someone of pseudoscience.
Anywho, if you think I'm just one big honking idiot and don't want to hear from me again regarding the matter, just say so. I just wanted to get my 2 cents in.