Ive mostly followed the main quests, done a few of the side quests. Ive just been playing the last couple of hours and theres a mission to collect some stuff in a place and no joke i whacked the resident large guy with large weapon about 50 times and he wouldnt go down. im out of medpacks, out of materials, out of patience. i think im doing it wrong.
The companion app can help with that. Back when I played through the game I got more medpacks from that than I ever needed.