Lol. Not any substantial difference between the two then. Honestly, both series look pretty interchangeable to me.
I'm kind of surprised people haven't described the differences between TLOU gameplay and UC gameplay in more detail, because they have little in common. The following comparison is between the two games on
hard difficulty.
Uncharted has regenrating health, TLOU does not. In Uncharted ammo is very rarely an issue, in TLOU you have to manage your ammo carefully and search areas and optional paths to find more. In Uncharted you generally get to use two weapons that enemies drop in any given area. In TLOU you keep any weapons you find and can use them all at any time. Uncharted does not have weapon upgrades, TLOU does. Uncharted does not have ability upgrades, TLOU does and you have to explore areas to get these upgrades.
TLOU has item crafting, Unchrated does not. TLOU enemy AI is better and more realistic than UC AI. The gunplay of TLOU is far more weighted an enemies go down and stagger in far less hits. The melee of TLOU is more important, and you have access to many different tools such as smoke bombs, mines and molotovs for which you get the resources by exploring and looting. Then there is the entire infected thing, they behave more predictably than humans but have abilities humans don't.
I could go on, but in summary gameplay wise Uncharted and TLOU have almost nothing in common expect that they loosely share the same genre, a 3rd person shooter.