I really notice the blurring when upscaling a non-native resolution onto my 4k display. Have tried variants between 3200-3600... definitely not sharp enough for me.
What I have found to be ideal is run the display at native res, albeit at an unorthodox aspect ratio. For computer use on a 4k 65" inch display, I've found 192 : 95 to be the ideal ratio. This amounts to a 3840 x 1900 resolution using the CRU in Nvidia. It's 13% less the number of pixels of 4k, and makes windows scaling soooooo much better. I can actually use my TV as a monitor. The benefits in games of a wider aspect ratio is is immense compared to 16:9, and you get a 13-15% performance boost. Unlike 21:9, 192:95 actually has height to it and does not feel too narrow!
The only downside is that this will create black bars, but compared to what 21:9 would be on a 4k display (3840 x 1600), the added 300px @ 3840 x 1900 is a night a day difference.