It's definitely going to be sci-fi, considering a props designer job posting on their website includes "Able to design realistic to sci-fi props". Also this was found by Superannuation:
http://kotaku.com/5977750/quantic-d...xseeds-surprise-killer-game-and-other-secrets (a GAF insider with a pretty good track record regarding QD also said the
PS4 game would be based on the Kara tech demo)
They hired the senior AI programmer who worked on Thief. Tasks include the programming of crowds and dynamic avoidance (such as people-vehicle). They are looking for a senior online programmer hinting at MP support (Omikron was supposed to have MP before it was dropped). A concept designer they hired is specifically focussed on designing original vehicles.
Beyond: Two Souls started as Project Infraworld, which was cancelled together with the Omikron sequel in 2003. Now they brought it back as Beyond. The Omikron sequel was never officially cancelled. Finally, they just hired a senior designer back who worked on the Omikron sequel and left the company in 2005. On his profile he says: "Back to the roots and working on an exciting project on PS4".
All of this is leading me to believe that we are getting a sci-fi Omikron spiritual successor on PS4 including themes from Kara and quite possibly set in an open world city.