Ranked in order of first month sales:
Uncharted 4 - Last of the Drake saga. Graphical showpiece. Will have excellent reviews. Big marketing push from Sony since it's their biggest exclusive these days. Pretty obvious choice for #1.
DOOM - The return of the king. Even though the franchise has faded away over the last decade, it's still the most well known franchise in this list, and there will be a big marketing push that reminds people the franchise is back. The campaign experience will be deemed something fresh and a lot of fun.
Overwatch - I haven't been following this game much, but it seems to have a big following since it's a new Blizzard franchise. It looks to be a very polished experience. Will review well I'm sure. Blizzard doesn't release stinkers.
Battleborn - This game is too trendy to fail. It will do OK and have its fanbase.
Mirror's Edge - On the flip side, this game isn't trendy enough. This game looks great and I'm sure it will review well. EA will give it a decent push I'm sure. But I just don't think a parkour game can make a big splash. I'd love to be proven wrong. It will still do alright in the end though.
Teenage Mutant Ninja Turtles - This looks like a really good game, but there's no local co-op, so that will turn off a good chunk of buyers (including myself).
Homefront - I didn't even know there's a new Homefront. lol