'El clasico' in Spain beween Barcelona and Real Madrid at the Nou Camp, and the 'Old Firm' derby in Scotland between Glasgow Rangers and Celtic at Ibrox Park.
The Barcelona-Real Madrid match is a clash between cultures as much as a clash between two soccer teams.
Barcelona the capital of Catalonia - against Madrid the capital of Castilla.
This match virtually brings Spain to a halt - and soccer matches don't come any bigger than that.
Real travel to the Nou Camp coming off a 6-1 win over Albacete which elevated them to second place in the standings and brought them to only four points behind league leaders Barcelona - while last week, Barca lost for the first time this season, going down to Real Betis.
So as joint-pretenders to the Spanish title, this is a must-win match for both clubs.
And both clubs are packed with match-winning soccer stars.
Barca have 24 year-old Brazil star Ronaldinho who along with the Portugal international Deco are the creative playmakers of the team - and the magical African Player of the Year, Cameroon striker Samuel Eto'o - who has tallied nine goals so far this season.
Real Madrid in return can boast Zinedine Zidane, Raul, Ronaldo, Beckham and Michael Owen.
Form means nothing in such super-derby games - but overall Barcelona looks the better balanced side - and it will take an inspired Madrid performance to grab the full three points from the Catalans.