Remember Me developer Dontnod Entertainment previously said that it's not trying to make a statement by putting female characters in lead roles, but that doesn't mean doing so is easy.
According to a recently released developer diary for the game, Dontnod encountered some resistance to the idea from publishers.
"Square is basically the only publisher who didn't want to change anything about the game," Dontnod Creative Director Jean-Maxime Moris said. "We had other publishers telling us to make it a male lead character, and Square didn't even question that once."
http://www.gamespot.com/articles/other-publishers-told-us-to-make-it-a-male-lead-ch/1100-6424577/
We've had a thread about the developer diary already but I imagine not everyone saw it and the topic itself is discussion-worthy.