Not particularly if the RE character in question is, say, Wesker. Then it's more like superhuman badass in a trenchcoat from an M rated game.A Link to the Snitch said:Don't you think that would be filling a niche that Snake already covers?
Gun-toting realistic character from an M rated game
That said, Capcom only really has two truly iconic characters. One of them is Ryu, and the other isn't Wesker. Ryu might work, especially if SFIV is getting a Wii version.