I will agree that Comey hurt her. But again many concerns were raised during the primaries about the stupid email server and all where ignored or brushed off.
She handled the entire thing stupid as fuck. She knew she was planning on running, she knew it was shady, she knew shit was coming out and the FBI was going on a witch hunt.
No big deal though, nobody cares! Well it turns out people care a lot more about potential national security issues than "locker room talk"
This, and, Obama was also an anti-establishment figure. Thats why he won the primary in 2008 and people still had enough hope in him during 2012. But then if you have "the" dem establishment (the same one that helped inact trade laws that hurt your communities, both white and black) come in and ride on the coat tails of Obama, people get turned off. Take the "public vs private message" thing. The issue was hardly refuted by the Hillary campaign, and in the debate it was mentioned for a few seconds and she didn't really give a good answer. She just deflected to Russia. Russia is a separate issue.