Garth Ennis' work on Hellblazer and The Preacher are some of my favourite writing in comics. They're vitriolic, sure, but they have a real heart at the core. Hell, Hitman is a lot of damn fun and his Dredd/2000AD stuff veers from charmingly cheeky to downright badass (I don't care what anyone says, Judgement Day was awesome).
The Boys though is simply mean for the sake of it. Kind of like Mark Millar's mid-to-late stuff.