No, for the reason that there are scenes with Goku from later seasons that I really enjoy, and couldn't imagine the series without them e.g. Goku on Namek, the Goku vs Majin Vegeta part of the Buu saga, Goku and Gohan in the Room of Spirit and Time, some others I can't call to mind due to not having watched the series in a while. Also I generally like Goku's relationships with other cast members- Gohan, Piccolo, Vegeta, Trunks, etc. and what those relationships add to the show. Basically it really wouldn't be the same without Goku, for me.
That said, I agree with those who have said that it's a shame Gohan's build-up as the new main character went to waste. I think the Buu saga would have been improved as a Gohan, Goten and Trunks based story, with Piccolo as the adult/mentor figure and the lesser-used cast members worked into the storyline in an interesting way.
The entire Buu saga sucks and makes no sense.
Goten and Kid Trunks are a joke. How can they be super saiyans? What have they gone through?