It's gonna be a huge year after relatively dry 2021.
The biggest one for me is Elden Ring, easily. This is like a different tier of gaming, hard to compare... but if that game didn't exist it would be GoW Ragnarok with TLOU Factions 2 close second.
I'm pretty sure Horizon 2 will be a great sequel, I preordered SIFU and that's more gaming till spring than I can make time for. I might be getting Dying Light 2 sometime later.
Amazing AA lineup as well, can't wait for release dates of Stray, Replaced, Somerville, Scorn, Trek to Yomi...I'll be probably gaming even more due to gamepass ultimate discovering other games that I missed of recent and I hope Sarfield turns out great. That will be soon after the full release of Darkest Dungeon 2.
I think Ghostwire Tokyo looks very interesting and is also on my list.
I wouldn't hold my breath for Calisto Protocol or Hellblade 2 in 2022, but we should get some news.