A strong character doesn't necessarily mean a noble character, it means a well written character. The trio of GTA V at least have fleshed out back stories, they go through a character arc, they occasionally express feelings. They're not the strongest characters in gaming, but they're fleshed out to some degree. None of the women in the game get anywhere near the same treatment. They're all one-dimensional cliches and plot devices.
No one in the game outside the main trio has any meaningful depth or development though, it's not just the women. They're all there in service to main three. Lester serves no purpose other than being the brains. Lamar is simple comic relief/bumbling idiot and shows absolutely zero change over the game. I would be very interested in a female protag for a GTA game though, if not just a BoGT or TLatD style expansion.