I doubt it. None of nomuras stuff is m rated.
Versus was most likely going to be just by the nature of the violence and darker subject matter.
And ACC and Crisis core...even though they had tons of blood and death they were still not considered 'adult's only' stuff, so i dunno.
It seems like ESRB just rate whatever they want however they want.
But the subject matter involved like total genocide of an entire part of a city, Barrets hometown being genocided and his best friend killing himself because he could not take the mental breakdown of those events...there was heavy ass shit in the original game, that probably could not synch with just a 1:1 realization of each scene.
I think the humor will be toned down definitely but there will be certain scenes present so not everything is serious