My advice for anyone picking up a Vita tomorrow:
Buy Uncharted: Golden Abyss.
Seriously. Do it. It is amazing.
It doesn't matter that the game is on a portable system or that it wasn't developed by Naughty Dog. It seriously looks and plays exactly like an Uncharted game. In fact, I honestly think it is better in every way (graphics, story, gameplay, etc.) than the first Uncharted.
I'm a few hours into it and I already like it more than U3.