I'd really hope they do it different to Wii anyway.
Make the lobbies far more direct. Just start the game, pick online multiplayer and right away find yourself in a regional text chat (able to parental lock this display outside friend chat too) and a list of created city lobbies (that you can filter to only show non-full or non-password protected or lobbies that have any of your friends in them, etc) showing the name chosen and other data, like how many players are in, HR, etc, and with the option to change to any other region for both the chat room and the lobby list (the latter could also be unfiltered worldwide). Basically Diablo II style with extra conveniences like the friend lobby filtering, none of that choosing server, city, gate, and so on before finally getting in game ready to pick a mission, and all the options there as truly optional rather than a process you have to pick every time you start the game. More than 4 players per city would be nice too, so you could in-game chat with more of your friends and swap groups around as needed to help each other best when in the city.
It could also be possible to forgo even that simple process by adding another option next to "online multiplayer" for "friends only online multiplayer" or something and just look for online friends, just in the 3DS friend list, none of the other stuff, then if they're already in game join whoever's lobby you want (seeing the name and other info again), if they're not already in game then be able to invite some and start a new lobby from that screen right away. Basically the same process as above but some of it handled in the background hidden from you with a simpler interface and simpler but adequate functions when you just want to do that.
There should be both in-game (as in, the city and actual hunts) text and voice chat too, and either or both of these functions able to parental lock into friends-only or lobby-only or neither too (also just as a simple tick option in a menu, so you don't have to parental lock every time you want to temporarily disable something for any reason, like being in public). Also, the missions in the hunting board should show the time left or taken on them, so you can know upon joining a lobby how much longer it may take for hunters to return to the city. At least after you know the game and figure how long things may take for people.