Yes, it will need drivers certainly. But that is not typically an issue. Or isn't one long term.If the final version doesn't use HDMI, but uses wireless whatever, we may have a problem. More likely, we will have a problem getting accelerational data out of it over USB (need drivers) and tracking the lights with a PS Eye (need drivers).
As for wireless though, that shouldn't be an issue either. Sony can't go back in time and change the PS4. It stills has the same I/O it launched with. Any wireless solution would hook up to the PS4 HDMI and then transmit to Morpheus. In other words, it would work with any HDMI. Granted a wireless solution would likely cap resolution, but I don't believe OR is looking to do anything beyond Morpheus in that regard anyway?