I'm really torn here.
On the one hand, the spectacle of Monster Hunter would absolutely benefit from the big-screen treatment - we've seen this already with Tri on the Wii. Sharp, HD graphics (sorry, Wii) and a good controller could only enhance the precision gameplay as well.
On the flip side, I have 100 hours logged on 4 Ultimate for 3DS (single player - felt I got my money's worth, even though I realise this is predominantly a multiplayer franchise). With a third-party grip and the New 3DS, I never once felt this game was anything less than eminently playable. I also do a majority of my gaming on handhelds these days.
TLDR; Whilst excited by the prospect of a proper, HD Monster Hunter, I am also concerned about the "death" of traditional handhelds. Dunno WTF I'll do once the 3DS and Vita stop receiving support. Certainly not mobile gaming on a phone. Yuck. Best scenario for me would be if the Switch turns out to be a success, and a version of Monster Hunter releases for it. However, that's a pretty big "if" given Nintendo's recent track record, and the seeming reluctance of the West to embrace handheld gaming.