I'm using Performance Lasso to keep my game locked at high prority. (I said last night that I wouldn't buy this port, but... it's Dishonored ffff) When the game is actually running at high priority, it runs significantly better - I'm holding 60fps almost all the time now on an oc'd 970 and 4790k at a mix of high and medium settings at native 1080p. I just approached Karnaca on the Wale, which was a segment that I read a user or two having frame drops during, and my game held at 60 throughout.
However, I did run into the issue that the game would revert back to low priority after a few minutes of gameplay. I think I've fixed that, though - I'll let y'all know in an hour or so if it really works, but here's what I did -
right click the Dishonored2.exe process in Process Lasso and set a new watchdog rule. Customize the rule so that when the watchdog detects that Dishonored 2 is using more than 10 or 15 percent of the CPU for more than five seconds at a time, the watchdog will automatically set Dishonored 2's priority to High if it isn't already. I've had the game idling for 45 minutes now and it's still set to high - I'm going to play for a little while now and see if it continues to work. And like I said, this tweak offers up a pretty huge performance boost as far as I can tell, or good enough at least that users running mid end or slightly better hardware can enjoy the game. (I'm also using the 1 frame rendered tweak as well.) I'm playing at 1080p on a 60hz monitor and aside from the aliasing I'm relatively satisfied with the performance I'm pulling now.
I've been using Rivatuner to lock my game to 60fps and I've been using the mouse smoothing tweak as well. Before I implemented all these tweaks, playing through the tutorial, I definitely noticed the judder that you guys were describing. Since I've implemented all the tweaks I described in this post, I haven't had any problems with it outside of brief loading screens. Hopefully this mess is patched up soon and users will no longer have to resort to heavy tweaking in order to run this game well. And for what it's worth, the game is really, really good, it just runs like shit :L