I've mostly shelved Fallout 4 for now, after about 10 hours. The combination of the the clunky combat and awful UI have been enough to make the game very unenjoyable for me. I love the world Bethesda built as usual, but I really do not enjoy playing in it. After a few days hiatus, I tried again last night and concluded it's not something I'll be able to adjust to. The gunplay is just awful and it's turned me off from the game entirely. Fallout 4 is probably my biggest gaming disappointment of the past decade.
Man, that really sucks. I think the gunplay is serviceable and this game will likely be in my top twenty of the last decade.