I enjoyed playing my male paragon through ME1 and 2 that I didn't think twice about playing through as a renegade femshep. When I finally did however, I found it to be an entirely different experience and never had more fun with the game!
The origin choices even fleshed out a great backstory for her. Raised on a colony and saw her family and friends slaughtered by Batarian raiders, then when she finally was assigned to a squad in the Alliance military, thresher maws ripped apart everyone leaving her the sole survivor of the massacre. From that point on, she didn't trust aliens as a whole and always sided with human interests. (She even holo high-fived The Illusive man at the end of 2)
She flirted with Kaiden, but in the end saved her friend Ash (chicks before dicks). Liara wanted some hot human love, but she wasn't really into other woman, let alone blue ones. Jacob wasn't her type and she friend-zone'd Garrus. Thane was too scaley (even though the hallucinogenic effect intrigued her). Dr. Mordin's intelligence and wit appealed to her, but he shot her down rather quickly so she ended up staring at an empty corner of her desk in the captain's room all emo when the time came to hit the Omega 4 relay. Poor Alex Shepard...