I always had a thought like what if the sequel took place in China. Like some InGen executives decide to sell their secrets to the Chinese etc. They build a hell of a new Park called Jurassic World in Inner Mongolia. It makes a lot of money for the executives but it's also a way for China to show it can go above and beyond what the Americans did in the first films.
They hire Malcolm to check it out etc. Bring Dr. Grant as well. And at the end, the dinosaurs aren't able to be controlled anymore and escape and breed like crazy in all parts of Eurasia. You have reports of Raptors tearing apart tigers in India, you have Triceratops decimating polar bears in Siberia or something. Probably show mountain goats in Tibet being picked apart by Pterodactyls.
Not have it be as heartfelt in a sense, but have some more elements of horror, futility and humanity once again playing god.