Picked mine up at Saturn (midnight launch), they had the machine with no game for 222 so I sprung for that. Launch software will inevitably drop in price (apart from Nintendo stuff) so I'll wait and plough through my DS backlog.
The quality of the machine is very nice, has a solid feel to it. Bought the cosmos black and am pretty satisfied, didn't like the turquoise sheen of aqua blue that much. It actually has a sort of gradient running from black to dark grey, looks nice! Buttons, dpad and slide pad all feel very good, but I only played around for a bit. Touchscreen is awesome coming from a DS phat, very responsive, been using my thumbs exclusively and had no problem using even the small software keyboard (I have quite big hands too). Screens are great quality too.
Setting up wifi is painless and I'm glad it accepts modern security settings now. DLed the update and the 3D film is quite amazing I must say (although sometimes coming with high compression artefacts). Can't wait to see more 3D movies on that thing. Mii maker worked surprisingly well (refinement needed of course) and face raiders is hilarious. AR stuff is really neat too. I didn't have too much problems loosing the 3D but fast and sudden movement makes the objects look janky. Been running the brightness on max with no power save and wifi on for around 2 hours this night (AR, Mii maker, photos etc.) and there was still plenty left on the initial charge - take it for what you will.
Oh and no headaches, nausea etc. after two hours of doing stuff at almost max 3D - although it has to be said that I am one of these people who can watch even a very long 3D movie without any problems.