The key difference and biggest problem with Resident Evil 5 on Move is the fusing of camera and movement commands to a single stick. On a normal controller, I would use the twin analog sticks to control my character and rotate the field of view separately.
With Move, there is only one thumbstick. My character always faced straight ahead because pushing left or right meant turning my whole view. Such a limitation in an action game is a serious handicap, even one with slow-moving enemies like zombies.
Those zombies didnt stand a chance, however, because Move offers a significant advantage over traditional controls. The ability to point and shoot directly at my targets sent my accuracy rate sky high. I also enjoyed the new knife control, where a shake of the Move wand would trigger a quick knife strike.