I have the best luck on closer street... and the key is to just push the multiplier up real quickly and THEN inflict a lot of pain.
I start by hitting the construction guy + crates up near the train tracks on the right and stay on the platform (x7 - 9 in one shot), then the train hits you and I veer off into the road and ooch into the explosive crate, then the exploding sewer cover (x15 by then sometimes) and THEN position myself for each car (and the biker) that comes by. As a grand finale, if you can work you way onto the other street and into the subway. And the rest is luck
I see there's a pretty good amount of vids on youtube already:
http://youtube.com/results?search_t...uery=pain ps3&search_sort=video_date_uploaded One showing off the "train" start I've been using.
The game was pretty much made for YT. Can't BELIEVE they didn't release it with the replay d/l feature.