I was talking about it in terms of Nintendo's orientation. Y and B are in the same spots as X and A on the Xbox controllers... It's confusing.
Resident Evil 6 uses A to run and X to collect items. On Xbox, these buttons are right near the stick and can be accessed fastest. On Wii U Pro, you would have to change these actions to Y and B to keep them in the same position on the diamond.
But Wii U's Y and B are farthest the stick, so this would make them the slowest buttons to access. So, it works out best to reverse the placement of each action on the diamond and use X and A as the main buttons, even though the feel of the controls is fundamentally changed by making the diamond backwards like this this.
Steam's controller will map buttons just like Xbox by default, which means running in RE6 would still be on A, the button farthest from the trackpad. X-Y and A-B would have to be reversed to prevent all the extra reaching that would result from that, just as they are on the U Pro.
It's not a major problem but it's something worth noting, as I have had to adjust control schemes to compensate for the U Pro's reversed stick position. Steam will allow this to be done easily but I'm concerned about whether on screen prompts will be harder to follow if all the buttons are reverse mapped.