Dark Souls 3 point down without contest. No idea how it hasn't been mentioned already.
Get R1 spammed by some ganking scrubs with their dark swords and then they all point down.
Instant Alt+F4
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Comes just after applause for me.
For me, the Well, What is it? is hilarious so even when it's used as a taunt, I find it too fun to not laugh so I never get angry even when I lose in the worst possible way and they start spamming it.