Anime had its mainstream moments with DBZ, Naruto, and AoT, but when the most popular anime in Japan are blatantly driven by over-seualizing characters because fans eat that shit up, anyone coming into the genre is bound to have their "this is messed up moment" between 3000 year old dragons, schoolgirls fighting in string bikinis, and jiggling boobs.
Which sucks, because Paprika was supposed to show the world the impossible possibilities anime could visually portray. Paprika is unfilmable for that very reason; its whole plot depends on what is wholly unique to the medium of animation. Anime could have been a host to a new wave of creativity and techniques, but it was more profitable to pander than to create cool new worlds. Don't get me wrong, I know the counter-examples to this but when something like "Monster Musume" becomes popular over a glorious piece of weirdness and creativity like "Nichijou", it shows where the priorities are at.