Game and Wario doesn't make sense to me as a pack in. Mario is the only good choice right now to replace Nintendoland. He's the familiar face the masses know, and in the current climate where Nintendo desperately needs to move hardware, he's the guy you need bundled with the system.
If they aren't doing Mario, then Mariokart is a MUST. That's the one other family friendly franchise, consumers know and love, that can move tons of systems. Considering we don't even know if Mariokart is releasing this year, I'm going to stick with NSMBU as the bundle. Possibly with a free bonus Luigi DLC download.