I'm no CVXfreak but I own every mainline RE, the GC remakes and some spinoff titles like UC, so you can say I'm pretty invested in he franchise. For me personally, "RE" died with RE5. I didn't like the direction Capcom went for.
This trailer does nothing to me, RE wise. I must say the Leon parts look interesting, but wow @ steroid Chris doing a janky version of Gears of War, fighting armed enemies. That stuff looked as janky as the armored "cover" encounters in the final stages of RE5 were. Those few seconds turned me off on the game already. It's a bit unfair though and I will of course buy the game, but I guess I suffer a bit from oldmancloud syndrome. This is not the RE as I would like it. (slow, methodical, puzzle, creepy remote location). But I can understand the direction Capcom went with it. To me it has become more of a Dead Rising type game which takes itself seriously.