I figure Retro's new game is a near-lock for E3 this year. They've consistently had 3 year development cycles, and have had DKCTF in the bag since November 2013. I recall a few high profile hires since Tropical Freeze came out, but not any departures (that I know of).
Nothing they announce could disappoint me. DK, Metroid, Gritty Ice Climbers reboot. I'm on board. I do hope that NX will allow them to really wow the industry again graphically. Metroid Prime blew everyone the fuck away with its graphics in 2002, and it's about time they got to really flex their muscles again.