I dislike gore for gore's sake, but depending on how the body-horror stuff is tied in thematically it could be more acceptable to me. If mutilating yourself is a side effect of committing violence, it's at least different than just going around ripping enemies apart as graphically as possible just for kicks even though you're apparently heroic.
It does remind me a lot of Berserk's nightmare-on-earth setting, especially concept art. The enemy designs are awesome/disturbing. It's interesting that they may be degraded people who have gone down the main character's path before.
Not sure if my squeamishness will make this unpleasant for me to play, but I'm definitely curious about how it comes together.