Judging by the reviews, the game seems to be close enough to the first one, which i really liked , so i can't wait to play it myself.
Also i don't have problems with criticism toward the show or even the game, but let's be fair, if the game is any close to the first game, basically 90% of its humour is based on references of the TV show, so if you don't like the show, you'll won't enjoy the game.
If anybody watches South Park religiously or even from time to time, but don't enjoy any character, joke, reference, commentary or satire, i don't know why the hell are you torturing yourself by watching the show.